CONTENTS:

Background

Structure

Molecular Biology

Journal Review

References

Links

Authors

References

Works Cited

Fields BN, Knipe DM, Howley PM. Fundamental Virology, 3rd edition; Raven Publishers: Philadelphia, 1996.

Fritz, J. Adenoviral Vectors for Gene Transfer. http://www.mc.vanderbilt.edu/gcrc/ geneadeno.html.

Gjerset, A. Turla, T. Sobol, E. Scalise, J. Mercola, D. Collins, H. and Hopkins, J. Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53. Mol. Carcino., .4, 275-85 (1995).

Knowles, Michael R., et al.  A Controlled Study of Adenoviral-Vector-Mediated Gene Transfer in the Nasal Epithelium of Patients with Cystic Fibrosis.  The New England Journal of Medicine.  Vol. 333. No. 13.   September 28, 1995.

Kock, H. Harris, M. Anderson, S. Machemer, T. Hancock, W. Sutjipto, S. Wills, K. Gregory, R. Shepard, H. M. Weatphal, M. and Maneval, D. Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo. Int. J. Cancer, 67, 808-815 (1996).

Levy J, Fraenkel-Conrat H, Owens, R. Virology, 3rd edition; Prentice Hall, Inc.: New Jersey, 1994.

Li, R. Sutphin, PD. Schwartz, D. Matas, D. Almog, N. Wolkowicz, R. Goldfinger, N. Pei, H. Prokocimer, M. and Rotter,V. Mutant p53 protein expression interferes with p53-independent apoptotic pathways. Oncogene, 25, 3269-77 (1998).

Merkle, C. Fritsche, M. Mundt, M. Jähne, R. and Groner, B. Transcriptional regulation and induction of apoptosis: implications for the use of monomeric p53 variants in gene therapy. Gene Ther., 12, 1631-41 (1998).

Nielsen, LL. Lipari, P. Dell, J. Gurnani, M. and Hajian, G. Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer. Clin. Cancer Res. 4, 835-46 (1998).

Ogawa, N. Fujiwara, T. Kagawa, S. Nishizaki, M. Morimoto, Y. Tanida, T. Hizuta, A. Yasuda, T. Roth, J. and Tanaka, N. Novel combination therapy for human colon cancer with adenovirus-mediated wild-type p53 gene transfer and DNA-damaging chemotherapeutic agent. Int. J. Cancer. 73, 367-370 (1997).

O’Malley, Bert and Daqing Li. Gene Therapy for Salivary Gland Cancer. Annals New York Academy of Sciences. Vol. 852. pgs. 163-170. April 15, 1998.

Sander, David M.  All the Virology on the WWW.   www.tulane.edu/~dmsander/WWW/335/Adenoviruses.html
February 16 ,1999.

Weller, M. Predicting response to cancer chemotherapy: the role of p53. Cell & Tissue Research., 292(3), 435-445 (1998).

Zalcman, G. Schlichtholz, B. Trédaniel, J. Urban, T. Lubin, R. Dubois, I. Milleron, B. Hirsch, A. and Soussi, T. Monitoring of p53 autoantibodies in lung cancer during therapy: relationship to response to treatment. Clin. Cancer Res., 6,1359-66 (1998).